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Spectinomycin Hydrochloride and Lincomycin Hydrochloride Soluble Powder

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[Veterinary Drug name]

General name: Lincomycin hydrochloride soluble powder

Product name: Slow stop

Spectinomycin and Lincomycin Hydrochloride day Powder

Yansuan Daguanmeisu Yansuan Linkemeisu Kerongxingfen

[Main ingredients] Dacamycin hydrochloride, Lincomycin hydrochloride.

The product is a kind of white powder.

Pharmacodynamic Macromycin is an aminoglycoside antibiotic, which has moderate inhibitory effect on a variety of gram-negative bacilli, such as Escherichia coli, Salmonella, Shigella, proteus, etc. It is sensitive to streptococcus, pneumococcus, Staphylococcus epidermidis and some mycoplasma (such as mycoplasma gallinaceus, Mycoplasma Turkey, mycoplasma synovium, etc.). To grass green streptococcus and staphylococcus aureus much insensitivity. Usually resistant to pseudomonas aeruginosa and treponema pallidum. Intestinal bacteria showed extensive resistance to macromycin, but did not show cross-resistance with streptomycin. Lincomycin has good antibacterial activity to anaerobic bacteria, such as Clostridium, digestive coccus, digestive streptococcus, clostridium tetanus, clostridium perfringens and most actinomycetes. Lincomycin mainly ACTS with the 50S subunit of the bacterial ribosome, affecting protein synthesis by inhibiting the elongation of the peptide chain.

Pharmacokinetic macromycin was absorbed only 7% after internal administration, but remained at a high concentration in the gastrointestinal tract. The tissue concentration of the drug was lower than the serum concentration. It is not easy to enter the cerebrospinal fluid or eyes, and the binding rate of plasma protein is not high. Most drugs are excreted in their original form through glomerular filtration. Lincomycin had poor internal absorption and bioavailability of 30%-40%. Mixed feeding can reduce the absorption rate and amount. The chicken was given 50mg/kg body weight (soluble in drinking water) for 7 days, and the plasma level of lincomycin reached 0.14ug/ml during the test, while the concentration of Macromycin was very small, which exceeded 0.1ug/ mL after 7 days of the test.

[Drug interaction] (1) Combined with lincomycin can significantly increase the antibacterial activity against mycoplasma and expand the antibacterial spectrum.

(2) The combination of lincomycin and anticholinesterase drugs can reduce the efficacy of the latter.

(3) Combined with erythromycin has antagonistic effect.

【 Function and application 】 antibiotics. For gram-negative bacteria, Gram-positive bacteria and mycoplasma infection.

[Usage and dosage] In terms of this product, mixed drink: 2 ~ 3.2g of 5-7 day old chicks per 1L of water. For 3-5 days.

【 Adverse reactions 】 No adverse reactions have been observed after using the prescribed dosage and usage.

[Precautions] Only used for 5-7 days old chicks.

[Sabbatical] no need to set.

[Gauge] 100g: Dacamycin 10g(10 million units) and Lincomycin 5G (C18H34N2O6S)

[Package] 100g/ bag.

[Storage] Sealed and kept in a dry place.

[Date of Production]

[Batch Number of Production]

[Valid until]

[approval number] veterinary drug (2015)153592602

· Veterinary Drug GMP Acceptance passed Enterprise (2015) Veterinary Drug GMP Certificate No.89

Production license :(2015) veterinary drug production license no. 15359

Manufacturer: Shandong Lugang Fuyou Pharmaceutical Co. LTD

Company address: No. 3388 airport Road, Lingang Development Zone, Jinan city

Website: www.lgfy.com tel: 0531-82687877

Fax: 0531-82687887 Zip code: 250107

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Add:3388 Jichang Road, Lingang Street, High-tech Zone, Jinan City, Shandong Province, China

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